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以4,6-二溴间苯二甲酸为起始原料,经过酰化、氨解、氯化以及成环反应生成配体4,6-二溴-1,3-双(2’-噁唑啉基)苯。后者先与醋酸钯作用后经离子交换最终得到对应的钳形化合物氯化[3,5-二溴-2,6-双(2’-噁唑啉基)]苯基钯(Ⅱ)。考察了该钳形化合物催化取代芳氯与苯硼酸的偶合反应。结果表明:除对氯苯胺外,其余各取代芳氯与苯硼酸的偶合均得到较高偶合收率,且带供电子基团的氯苯与苯硼酸的偶合收率要高于吸电子基团氯苯的偶合收率,这可能与钳形化合物中溴的吸电子性能有关。
Starting from 4,6-dibromoisophthalic acid, the ligand 4,6-dibromo-1,3-bis (2’-oxazole Yl) benzene. The latter by the first interaction with palladium acetate after ion exchange to obtain the corresponding clamp compound chlorinated [3,5-dibromo-2,6-bis (2’-oxazolinyl)] phenyl palladium (Ⅱ). The coupling reaction between the aryl chloride and phenylboronic acid catalyzed by the pincer compound was investigated. The results showed that in addition to p-chloroaniline, all the other substituted aryl chlorides and benzene boronic acids were coupled to obtain a higher coupling yield, and with the electron-donating group chlorobenzene and phenylboronic acid coupling yield higher than the electron-withdrawing group The coupling yield of chlorobenzene may be related to the electron-withdrawing properties of bromine in the pincer-like compound.