报告８个病种３２５例危重病患者血清胃泌素的测定结果并与５８例正常人对比。结果表明：危重病患者不管是否伴有消化道出血，其血清胃泌素均有意义地升高（Ｐ＜０．００１）。说明危重病患者有高胃泌素血症存在。并与消化道出血和ｐＨ值降低可能有一定关系。提示在危重病治疗时，不管是否有消化道出血，及早应用抑制胃泌素分泌的药物对保护胃粘膜，预防消化道出血可能有一定益处。 The results of the determination of serum gastrin in 325 critically ill patients in 8 diseases were reported and compared with 58 healthy controls. The results showed that: Serum gastrin was significantly increased in critically ill patients with or without gastrointestinal bleeding (P <0.001). Description of critically ill patients with hypergastrinemia exists. And may have some relationship with lower gastrointestinal bleeding and pH value. Tips in the treatment of critical illness, whether or not gastrointestinal bleeding, as early as possible inhibition of gastrin secretion of drugs to protect the gastric mucosa, the prevention of gastrointestinal bleeding may have some benefits.