香豆素致皮肤坏死是口服抗凝药的一种不常见并发症。本文报道1例患遗传性蛋白C缺乏症患者服香豆素后阴茎皮肤的坏死。患者33岁,男性,因反复腿部深静脉血栓住院,曾用肝素和华法令治疗无并发症。入院后病人用肝素静脉输注,第8天给予华法令。在每次20mg服用2次后48小时,病人感觉阴茎勃起疼痛,并继续加重,伴 Coumarin-induced skin necrosis is an uncommon complication of oral anticoagulation. This article reports the necrosis of the penile skin of a patient with hereditary protein C deficiency who received coumarin. The patient, 33 years old, was hospitalized for recurrent leg deep vein thrombosis and had no complications with heparin and warfarin. After admission, patients were given heparin intravenous infusion and warfarin was given on the 8th day. In each 20mg take 2 times after 48 hours, the patient feels penile erection pain, and continue to aggravate, with