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緒言:常用的磺胺类鈉鹽滴眼液有磺胺噻唑、磺胺嘧啶及磺胺乙酰三种,但由于磺胺类鈉鹽滴眼液容易变色,磺胺噻唑鈉及磺胺嘧啶鈉溶液很易产生沉淀,並且鹼性較高,故一般医院用得不普遍;又如用高濃度的磺胺乙酰鈉溶液滴眼时常發生疼痛,亦不敢大量採用,今为判明放置时間对变色程度及对滴眼的影响,产生沉淀的原因、时間及如何減少沉淀,鹼性較高是否須要調整pH,以及磺胺乙酰鈉溶液的高滲等問題,曾作了以下的一些实驗及文献总結: 試驗:(一)变色問題:試以上列三种溶液裝入不同容器,儲藏于室内,其颜色变化見下表。
Introduction: commonly used sulfa sodium eye drops are sulfathiazole, sulfadiazine and sulfaacetyl three, but because sulfa sodium eye drops easy to change color, sulfathiazole sodium and sulfadiazine sodium solution is easy to produce precipitation, and alkali Higher sex, so the general hospital is not used widely; Another example is the use of high concentrations of sodium sulfanilicate solution eye drops often occur pain, are not used in large quantities, this is to determine the placement time on the degree of discoloration and eye drops, The reasons for the precipitation, the time and how to reduce the precipitation, alkaline need to adjust the pH higher, and the sulfonamide sodium solution hypertonicity and other issues, have made some of the following experiments and literature summary: Test: (a) discoloration Question: Try the above three solutions into different containers, stored in the room, the color change in the table below.