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编辑同志: 自从1953年你报第八期刊載了“介紹便于小兒服用的磺胺混悬剂”一文后,在药房中把磺胺类药物調配成混悬剂發售者颇多,有些药房並加入矯味剂、芳香剂、着色剂等,这样就更便服用适口了。但也有些药房在应用上仍有不当之处,今提出討論于次: 1.在混悬剂中未加入碳酸氫鈉:我們知道磺胺类药物服用后,在体内(肝)部份乙酰化,使溶解度大降,甚易析出沉淀,沉积于腎脏及尿道中,能刺激腎臟,即所谓腎扰乱。多
Editor’s Comrade: Since 1953, you reported in the eighth issue of the “introduction of sulfa suspension for pediatric use,” a text, in the pharmacy, the deployment of sulfonamides as a suspension of a lot of sellers, some pharmacies and join Flavoring agents, fragrances, coloring agents, etc., so that it is easier to take palatable. However, some pharmacies are still not suitable for application. Discussions are now underway: 1. Sodium bicarbonate is not added to the suspension: we know that the sulfonamides partially acetylate in the body (liver) So that the solubility dropped, very easy precipitation, deposition in the kidneys and urethra, can stimulate the kidneys, the so-called kidney disturbance. many