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目的探讨染色体异常与男性生精障碍的关系。方法对429例生精障碍者进行外周血淋巴细胞培养,G显带染色体核型分析。结果检出染色体异常核型44例,检出率为10.3%。其中,无精子症、重度少精子症和少弱精子症的染色体异常检出率分别为15.8%、6.1%和4.7%,以无精子症最高。染色体异常包括性染色体数目、结构异常和常染色体异常,以性染色体数目异常为主。结论染色体异常是导致生精障碍的重要原因之一,生精障碍程度越高,染色体异常检出率越高。对生精功能障碍的男性患者有必要进行染色体核型分析。
Objective To investigate the relationship between chromosomal abnormalities and spermatogenic disorders in men. Methods Peripheral blood lymphocytes were cultured in 429 students with somatotrophic deformity. G - banding karyotypes were analyzed. Results Chromosome abnormal karyotype detected in 44 cases, the detection rate was 10.3%. Among them, azoospermia, severe oligozoospermia and oligoasthenospermia chromosomal abnormalities were 15.8%, 6.1% and 4.7%, with the highest azoospermia. Chromosomal abnormalities, including the number of sex chromosomes, structural abnormalities and autosomal abnormalities, the main sex chromosome abnormalities. Conclusion Chromosomal abnormalities are one of the major causes of dysbacteriosis. The higher the degree of dysbiosis, the higher the detection rate of chromosomal abnormalities. It is necessary for karyotype analysis in male patients with spermatogenic dysfunction.