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急性坏死性胰腺炎炎症和坏死过程的起动机制仍不清楚,治疗上除支持疗法外亦无其它有效方法.本文描述在用雨蛙肽引起大鼠急性坏死性胰腺炎后的生化和组织结构改变的消退过程,并比较胰泌素与两种CCK受体拮抗剂,丙谷胺和benzotriPt的保护作用.材料和方法:实验用大鼠15只禁食16～18小时后,每小时接受不同剂量的雨蛙肽(5～200μg/kg)皮下或腹腔内注射共7次,对照组注射0.9%氯化钠,于首次注射后9小时全部杀死.在研究胰腺炎时间过程和药物保护作用的实验中,用雨蛙肽50μg/kg腹腔内注射共7次.杀死鼠的时间同前.每次给予雨蛙肽前半小时,皮下注射不同剂量的丙谷胺或benzotript或胰泌素.另作下述实验:1.首次雨蛙肽注射后12小时杀死动物,观察丙谷胺或胰泌素的作用.2.研究在第三次注射雨蛙肽后给予丙谷胺或benzotript 4次的作用.3.研究丙谷胺或胰泌素对小剂量雨蛙肽引起的胰腺炎的作用.对部分鼠进行较长时间的实验观察.结果:皮下或腹腔内注射大剂量雨蛙肽可引起血清
The mechanism of the initiation of inflammation and necrosis of acute necrotizing pancreatitis remains unclear and there are no other effective treatments in addition to supportive therapy.This article describes the biochemical and histological changes after acute necrotizing pancreatitis in rats And compare the protective effects of secretin with two CCK receptor antagonists, proglumide and benzotriPt.Materials and Methods: Fifteen rats in experiment were fasted for 16-18 hours and then received different doses of (5 ~ 200μg / kg) were injected subcutaneously or intraperitoneally for 7 times in the control group, and 0.9% sodium chloride in the control group, all of which were killed 9 hours after the first injection.In the experiment of studying the time course and drug protection of pancreatitis , With aureobasidin 50μg / kg intraperitoneal injection of a total of 7 times to kill rats with the same time before each time to give the frog peptide half an hour before the subcutaneous injection of different doses of propylamine or benzotript or secretin.Also for the following experiment : 1. The animals were sacrificed 12 hours after the first injection of phytolaccae and observed the effect of proglumide or secretin 2. The effect of promethazine or benzotript 4 times after the third injection of the frog peptide was studied 3. The study Promethazine or secretin on the small dose of frog peptide cited Experimental observation pancreatitis action on the part of a longer time results rat: subcutaneous or intraperitoneal injection of large doses may cause serum caerulein