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目的研究臭椿Ailanthus altissima根部的化学成分。方法采用硅胶柱色谱和HPLC等分离方法,对臭椿树根正己烷萃取物的化学成分进行分离,并经波谱数据分析鉴定结构。结果分离得到了14个化合物,分别鉴定为20β-羟基达玛烷-24-烯-3-酮(1)、β-谷甾醇(2)、ocotillone(3)、5,6,7,8-四甲氧基香豆素(4)、尼洛替星(5)、isofouquierone peroxide(6)、20S,24S-二羟基达玛烷-25-烯-3-酮(7)、匹西狄醇A(8)、eichlerianic acid(9)、二氢尼洛替星(10)、12β,20β-二羟基达玛烷-24-烯-3-酮(11)、铁屎米-6-酮(12)、12β-hydroxy ocotillone(13)、20S,25-epoxy-24R-hydroxy-3-dammaranone(14)。结论化合物3、4、6、9、10、13系首次从该植物中分离得到。
Objective To study the chemical constituents of roots of Ailanthus altissima. Methods Silica gel column chromatography and HPLC were used to separate the chemical components of n-hexane extract of Ailanthus altissima, and their structures were identified by spectral data analysis. As a result, 14 compounds were isolated and identified as 20β-hydroxyDaMa-24-en-3-one (1), β- sitosterol (2), ocotillone (3), 5,6,7,8- Tetramethoxycoumarin (4), nilotinox (5), isofouquierone peroxide (6), 20S, 24S- dihydroxytamarane- 25 -en- 3-one (7) (8), eichlerianic acid (9), dihydnililixin (10), 12β, 20β-dihydroxymalane-24- 12), 12β-hydroxy ocotillone (13), 20S, 25-epoxy-24R-hydroxy-3-dammaranone (14). Conclusion Compounds 3, 4, 6, 9, 10 and 13 were isolated from this plant for the first time.