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血栓生成及其预防血管内膜受损后即开始一系列血小板和凝血反应而导致血栓形成,不同类型的血栓和栓塞具有不同的机理和发生途径;因而一种对血栓形成的某一途径有作用的药物对其另一途径可能作用很小。大动脉受损后,被显露的基底膜、胶原与微纤维和血小板相互作用,粘合成一层附着于内膜面的物质。血小板与胶原相互作用,释放出二磷酸腺苷(ADP),后者激活花生四烯酸合成前列腺素的反应,产生血栓素 A_2。ADP 与血栓素 A_2
Thrombosis and its prevention of intimal injury begins a series of platelet and thrombogenic reactions that lead to thrombosis. Different types of thrombus and embolism have different mechanisms and pathways; therefore, one of the pathways to thrombosis has an effect Of the drug may have little effect on another route. After damage to the aortic artery, the exposed basement membrane, collagen and microfibrils and platelets interact to form a layer of substance that adheres to the intima. Platelets interact with collagen to release adenosine diphosphate (ADP), which activates the reaction of arachidonic acid to synthesize prostaglandins, producing thromboxane A2. ADP and thromboxane A_2