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以脑电图、游泳机能和体重为指标,观察了氚水单次注入妊娠大鼠后对其仔鼠神经系统机能及体重发育的影响。实验是在15只雌性大鼠及其所产的120只仔鼠分 A、B、C 三组进行的。A 组大鼠于妊娠第1d(胚胎期),B 组大鼠于妊娠第13d(胎儿期)经腹腔注入氚水,使动物体水氚放射性浓度达到1.85MBq/ml(50μCi/ml)。A、B 两组仔鼠在子宫内受氚水照射的吸收剂量分别为0.59±0.01和0.51±0.01Gy,C 组为对照组。结果表明,A、B 两组仔鼠第18,32和36天龄基础 EEG 与对照组相比无明显改变,但32和36天龄仔鼠 EEG 对节律光刺激同步化反应和对声刺激的阻抑反应皆受到阻碍,A 组尤为明显。A、B 两组仔鼠第8和18天龄时游泳机能明显受阻,两组受阻程度相同。第5、8和18天龄时两组仔鼠体重发育不良的发生率皆有所增加,B 组更为明显。
EEG, swimming function and body weight were used as indexes to observe the effects of single tritiated water injection on the nervous system function and body weight of pregnant rats. The experiment was conducted in 15 female rats and 120 offspring of them born in groups A, B and C. Rats in group A were injected intraperitoneally with tritiated water on the 1st day of gestation (embryonic stage) and the 13th day of gestation (fetal stage) in rats of group A, so that the radioactive tritium concentration of animal body reached 1.85MBq / ml (50μCi / ml). The absorptive dose of neonatal rats exposed to tritiated water in groups A and B were 0.59 ± 0.01 and 0.51 ± 0.01Gy, respectively. C group was the control group. The results showed that there was no significant change in the basal EEG of the 18th, 32th and 36th days of age groups A and B compared with that of the control group. However, the EEG of 32 and 36 days old pups had synchronized responses to rhythmic light stimulation and to acoustic stimulation Inhibition of response were obstructed, especially in group A. A, B two groups of pups at the 8th and 18th day of age, swimming function was significantly blocked, two groups of the same degree of obstruction. At the 5th, 8th and 18th days of age, the prevalence of weight dysplasia in both groups was increased, while in group B, the incidence of body weight dysplasia increased.