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目的:观察中药制剂健脾消糖颗粒治疗糖尿病前期的临床疗效及对患者3种炎症因子白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(HsCRP)的影响。方法:将117例糖尿病前期患者随机分为治疗组和对照组,治疗组59例,对照组58例,两组均进行健康教育及生活干预治疗,治疗组服用健脾消糖颗粒和阿卡波糖片;对照组单纯服用阿卡波糖片。疗程均为6个月,比较两组治疗前后空腹血糖(FPG)、糖负荷后2 h血糖(2 hPG)、糖化血红蛋白(HbA1c)及IL-6,TNF-α,HsCRP的变化。结果:两组的炎症因子指标均有下降(P<0.05),与对照组比较,治疗组治疗后TNF-α,HsCRP下降更明显(P<0.01)。两组治疗后FPG,2 hPG,HbA1c水平均下降(P<0.05),与对照组比较,治疗组治疗后FPG,HbA1c下降更明显(P<0.01)。结论:健脾消糖颗粒和阿卡波糖片均能改善糖尿病前期患者FPG,2 hPG,HbA1c的水平,而健脾消糖颗粒疗效更满意,并能显著降低炎症因子水平。
Objective: To observe the clinical efficacy of Chinese medicine preparation Jianpi Xiaogan Granules in the treatment of pre-diabetic patients and the effects of three inflammatory cytokines including interleukin-6, tumor necrosis factor-α (TNF-α), high-sensitivity C-reactive protein (HsCRP) effects. Methods: 117 cases of pre-diabetic patients were randomly divided into treatment group and control group, 59 cases in the treatment group and 58 cases in the control group. Both groups were given health education and life intervention. The treatment group took Jianpi Xiaogu particles and acarbin The control group was treated with acarbose alone. The course of treatment was 6 months. The changes of fasting blood glucose (FPG), 2h blood glucose (2hPG), HbA1c, IL-6, TNF-α and HsCRP were compared between the two groups before and after treatment. Results: The indexes of inflammatory cytokines decreased in both groups (P <0.05). Compared with the control group, the decrease of TNF-α and HsCRP in the treatment group was more obvious (P <0.01). The levels of FPG, 2 hPG and HbA1c in both groups decreased after treatment (P <0.05). Compared with the control group, FPG and HbA1c decreased more obviously in the treatment group after treatment (P <0.01). Conclusion: Jianpi Xiaogan granules and acarbose tablets can improve the level of FPG, 2 hPG and HbA1c in patients with pre-diabetes, while the effect of Jianpi Xiaogan Granules is more satisfactory, and can significantly reduce the level of inflammatory cytokines.