该研究旨在分析大分割放疗(RT)在鼻窦恶性黑色素瘤术后局部控制中的效果。1998-2013年间,来自荷兰4个头颈肿瘤中心的63例术后RT患者纳入研究,比较传统分割RT(2~2.4 Gy/间隔;n=27)与大分割RT(4~6 Gy/间隔;n=36)的效果,评估局部控制率和毒副作用。结果:治疗后2年和5年局部控制率分别为63%、64%和47%、53%(P=0.73)。局部复发主要发生于同侧(92%)、照射野内(88%)。2例患者 The aim of this study was to analyze the effect of large fractionated radiotherapy (RT) on the postoperative local control of sinus malignant melanoma. Sixty-three postoperative RT patients from four Head and Neck Cancer Centers in the Netherlands were included in the study from 1998 to 2013 and were compared with conventional RT (2-4 Gy / interval; n = 27) vs. broad-cut RT (4-6 Gy / n = 36) to assess the local control rate and side effects. RESULTS: The local control rates at 2 years and 5 years after treatment were 63%, 64% and 47%, 53%, respectively (P = 0.73). Local recurrence occurred mainly in the ipsilateral (92%), radiation field (88%). 2 patients