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目的探讨宫颈鳞状细胞癌(SCC)患者病灶中zeste同源增强子2(EZH2)及p53蛋白的表达情况与临床分期及预后的关系。方法采用量子点荧光双重染色方法,检测中山大学附属第一医院2005年1月至2006年12月168例宫颈鳞状细胞癌组织病理切片中EZH2和p53蛋白的表达情况,分析这两种蛋白表达与宫颈癌患者临床分期、淋巴结转移、肿瘤复发、无进展生存期(PFS)、总生存期(OS)的关系。结果随着SCC分期的升高,EZH2和p53更多地出现共同表达,有淋巴结转移的病例组织中EZH2和p53蛋白共同表达阳性率显著高于无淋巴结转移的病例(P<0.05)。EZH2和p53蛋白共同表达阳性患者的PFS、OS均明显小于表达为阴性的患者(P<0.05)。结论 EZH2和p53蛋白在宫颈鳞状细胞癌病灶中的表达与其临床分期、淋巴结转移和预后相关。
Objective To investigate the relationship between the expression of zebra estrogen receptor 2 (EZH2) and p53 in cervical squamous cell carcinoma (SCC) patients with clinical stage and prognosis. Methods The double staining of QDs was used to detect the expression of EZH2 and p53 in 168 cases of squamous cell carcinoma of the cervix from January 2005 to December 2006 in the First Affiliated Hospital of Sun Yat-sen University. The expression of these two proteins And cervical cancer patients with clinical stage, lymph node metastasis, tumor recurrence, progression-free survival (PFS), overall survival (OS). Results EZH2 and p53 were co-expressed with the increase of SCC staging. The positive rates of EZH2 and p53 protein expression in cases with lymph node metastasis were significantly higher than those without lymph node metastasis (P <0.05). PFS and OS of patients with positive expression of EZH2 and p53 protein were significantly lower than those of patients with negative expression of p53 protein (P <0.05). Conclusion The expression of EZH2 and p53 in cervical squamous cell carcinoma of the cervix is related to clinical stage, lymph node metastasis and prognosis.