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目的:本课题通过对脓毒性休克急性肾损伤患者疗效的观察,探讨持续肾脏替代治疗(CRRT)联合乌司他丁的治疗作用以及对肾功能相关指标的影响。方法:对23例脓毒性休克急性肾损伤患者进入ICU后给予血尿素氮、血肌酐检测,随机分为两组,治疗组在CRRT后并联合乌司他丁治疗;对照组只用CRRT进行治疗。比较两组患者临床症状及肾功能相关指标(血尿素氮、血肌酐)的下降速度。结果:治疗后48小时,治疗组血尿素氮、血肌酐值明显下降(p<0.05),与对照组比较,差异均有统计学意义(p<0.05)。结论:持续肾脏替代治疗(CRRT)联合乌司他丁的治疗对脓毒性休克急性肾损伤患者的血尿素氮、血肌酐等指标有效降低,提高疗效。
OBJECTIVE: To investigate the therapeutic effect of continuous renal replacement therapy (CRRT) combined with ulinastatin and its effect on the indexes of renal function in patients with acute renal injury induced by septic shock. Methods: Twenty-three patients with septic shock and acute kidney injury were enrolled in ICU. Blood urea nitrogen and serum creatinine were measured and randomly divided into two groups. The treatment group was combined with ulinastatin after CRRT and the control group was treated with CRRT alone . Clinical symptoms and renal function-related indicators (blood urea nitrogen, serum creatinine) decline rate of two groups were compared. Results: At 48 hours after treatment, the levels of blood urea nitrogen and serum creatinine in the treatment group decreased significantly (p <0.05), and the differences were statistically significant (p <0.05) compared with the control group. CONCLUSIONS: Continuous renal replacement therapy (CRRT) combined with ulinastatin is effective in reducing blood urea nitrogen, serum creatinine and other indexes in patients with septic shock and acute kidney injury.