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目的探讨降钙素原(PCT)、超敏C反应蛋白(CRP)和白细胞(WBC)联合检测对新生儿感染性肺炎的临床价值。方法感染性肺炎新生儿188例,分为细菌感染组66例、混合感染组30例与其他组92例。同期非感染疾病新生儿180例为对照组。比较各组血清中PCT、CRP水平和WBC计数结果。结果新生儿PCT、CRP及WBC三项联合检测实验组、细菌感染组、混合感染组与其他组的灵敏度分别为81.2%、96.1%、83.2%、38.6%,特异度分别为73.4%、89.9%、66.4%、68.4%;联合检测的灵敏度与特异度均高于单项检测。治疗前,细菌感染组和混合感染组各指标比对照组均明显升高(P<0.05);治疗后,上述各项指标差异均无统计学意义。结论 PCT、CRP及WBC对于新生儿血清的鉴别诊断、疗效监测,指导抗生素用药及疗效评价具有指导意义。
Objective To investigate the clinical value of combined detection of procalcitonin (PCT), high-sensitivity C-reactive protein (CRP) and white blood cell (WBC) in neonatal pneumonia. Methods 188 neonates with infectious pneumonia were divided into bacterial infection group (66 cases), mixed infection group (30 cases) and other groups (92 cases). The same period non-infectious disease in 180 newborns as a control group. The serum PCT, CRP levels and WBC count results were compared. Results The sensitivities of experimental group, bacterial infection group and mixed infection group were 81.2%, 96.1%, 83.2%, 38.6%, specificity of 73.4%, and specificity of 89.9% in neonatal PCT, CRP and WBC combined tests respectively. , 66.4% and 68.4% respectively. The sensitivity and specificity of combined detection were higher than those of single detection. Before treatment, the indexes of bacterial infection group and mixed infection group were significantly higher than those of the control group (P <0.05). There was no significant difference between the above indexes after treatment. Conclusion PCT, CRP and WBC have guiding significance for the differential diagnosis of neonatal serum, monitoring the curative effect, guiding the use of antibiotics and evaluation of curative effect.