痛觉感受器的动作电位发放频率是衡量痛程度的主要参考因素。而超级化激活环核苷酸门控阳离子通道(Hyperpolarization-activated cyclic nucleotide-gated cation channel,HCN)是影响动作电位发放频率的主要通道之一。HCN通道家族包含四个亚型,HCN1、HCN2、HCN3和HCN4,它们都表现为在膜电位-60至-90 mV时超极化引起的内向电流,称为Ih电流。在心肌,HCN通道的激活引起的电流是驱动心脏起搏的主要电流。四 The frequency of the action potentials of the nociceptors is a major reference measure of the severity of pain. Hyperpolarization-activated cyclic nucleotide-gated cation channel (HCN) is one of the main channels affecting the release of action potential. The HCN channel family consists of four subtypes, HCN1, HCN2, HCN3 and HCN4, all exhibiting an inward current due to hyperpolarization at a membrane potential of -60 to -90 mV, referred to as Ih current. In myocardium, the current induced by the activation of HCN channels is the main current driving cardiac pacing. four