本文使用气相色谱仪新型氮磷检测器(NPD)测定服用正常治疗量氯丙嗪人的血清药物浓度,方法简单、快速、灵敏,取2ml血清其灵敏度达5ng/ml。方法是:氯丙嗪在碱性条件下,用有机溶剂反复萃取后,上气相色谱分析,选用异丙嗪为内标。以无药血清加入氯丙嗪标准品,得到相关较好的工作曲线(r=0.9996),并测定了10名精神分裂症患者的氯丙嗪血药浓度。 In this paper, a new nitrogen and phosphorus detector (NPD) was used to determine the serum concentration of chlorpromazine. The method was simple, rapid and sensitive. The sensitivity of 2 ml serum was 5 ng / ml. Method is: chlorpromazine in alkaline conditions, repeated extraction with organic solvents, the gas chromatographic analysis, the selection of promethazine as an internal standard. A good working curve (r = 0.9996) was obtained with no drug serum added to chlorpromazine standard, and the plasma concentration of chlorpromazine in 10 schizophrenic patients was determined.