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目的:探讨瑞芬太尼联合右美托咪定对脑功能区胶质瘤术中唤醒的临床效果。方法:收集我院行脑功能区胶质瘤切除术患者50例,随机分为实验组和对照组,每组各25例,对照组患者采用瑞芬太尼联合丙泊酚,实验组患者采用瑞芬太尼联合右美托咪定。比较术前与唤醒期间两组患者心率(Heart Rate,HR)、平均动脉压(mean arterial pressure,MAP)、唤醒时间、自主呼吸恢复时间、唤醒成功率、呛咳次数、术中躁动次数、术中知晓例数,其数据结果应用统计学软件SPSS 19.0加以处理。结果:两组患者术前HR、MAP比较无差异(P>0.05);与对照组相比,实验组患者HR及MAP较低(P<0.05);唤醒时间及自主呼吸恢复时间较短(P<0.05),唤醒成功率无明显差异(P>0.05);呛咳次数、术中躁动次数及术中知晓例数较少(P<0.05)。结论:瑞芬太尼联合右美托咪定对脑功能区胶质瘤患者心率及平均动脉压影响较小,且能够降低不良事件发生率,促进患者苏醒,值得临床推广。
Objective: To investigate the clinical effect of remifentanil combined with dexmedetomidine on intraoperative arousal of brain functional glioma. Methods: Fifty cases of glioma resection in our department were randomly divided into experimental group and control group, with 25 cases in each group. Remifentanil and propofol were used in the control group. The patients in the experimental group were treated with Remifentanil in combination with dexmedetomidine. The changes of heart rate (HR), mean arterial pressure (MAP), wake time, spontaneous breathing recovery time, awake success rate, choking frequency, intraoperative agitation frequency In the number of cases known, the data results using statistical software SPSS 19.0 to be addressed. Results: There was no significant difference in preoperative HR and MAP between the two groups (P> 0.05). Compared with the control group, HR and MAP in the experimental group were lower (P <0.05), wake time and spontaneous breathing recovery time were shorter <0.05). There was no significant difference in awakening success rate (P> 0.05). The number of choking coughs, intraoperative agitation and intraoperative awareness were fewer (P <0.05). Conclusion: Remifentanil combined with dexmedetomidine has little effect on heart rate and mean arterial pressure in patients with gliomas of brain function area, and can reduce the incidence of adverse events and promote the patient to wake up, which is worthy of clinical promotion.