一导言1940年Florey等分离青霉素并作为化疗剂使用后,陆续发现作化疗剂使用的抗生素有β-内酰胺类、四环素类、大环内酯类、氨基糖苷类等.微生物产生的β-内酰胺抗生素有青霉素、头孢菌素、头孢霉素、诺卡杀菌素、棒酸、碳霉烯类、单环内酯等.放线菌或细菌产生的碳霉烯已有近40种,青霉烯是非天然型的β-内酰胺,在天然界尚未发现.青霉烯是碳霉烯1位的次甲基变为硫原 Introduction In 1940 Florey isolates penicillin and used as a chemotherapeutic agent, one after another as a chemotherapeutic agent used antibiotics are β-lactams, tetracyclines, macrolides, aminoglycosides, etc. Microorganisms to produce β-endo Amide antibiotics are penicillin, cephalosporin, cephalosporins, nociceptin, clavulanic acid, carbaryl, monocyclic lactone, etc. Actinomycetes or bacteria produce carbaryl has nearly 40 species, Penicillium Alkene is a non-natural beta-lactam that has not been found in the natural world. Penem is the methine at position 1 of carbaryl turned into sulfur