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在二乙基亚硝胺诱发大鼠肝癌的过程中测定肝内酶 ACT、γ-GT、OCT、CPS_1以及 AKP,并作病理检查,观察灌喂健脾理气、清热解毒、软坚化痰方剂的中药组、西药组(Vit.C+Vit.E+Vit.A)和对照组的酶以及病理变化。结果:对照组在致癌过程中 AKP、ACT、γ-GT 增高,而 CPS_1、OCT 下降,中药能改变这种情况。西药组与中药组γ-GT、ACT、CPS_1存在显著差异(P<0.05)。病理证实:肝组织脂变、纤维间变、假小叶形成等变化以对照组最严重、西药组次之,中药组最轻。
The hepatic enzymes ACT, γ-GT, OCT, CPS_1, and AKP were measured in the process of diethylnitrosamine-induced hepatocarcinogenesis in rats, and pathological examinations were performed to observe the effects of invigorating the spleen and qi, clearing heat and detoxifying the stasis, and removing the toxic and decoy Enzymes and pathological changes in Chinese medicine group, western medicine group (Vit.C+Vit.E+Vit.A) and control group. Results: In the control group, AKP, ACT, and γ-GT increased during carcinogenesis, while CPS_1 and OCT decreased. Chinese medicine can change this situation. Western medicine group and traditional Chinese medicine group γ-GT, ACT, CPS_1 were significantly different (P <0.05). Pathology confirmed that changes in hepatic tissue lipids, fibrosis, and false leaflet formation were the most severe in the control group, followed by the Western medicine group, and lightest in the Chinese medicine group.