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【目的】研究人乳多不饱和脂肪酸(polyunsaturated fatty acid,PUFA)含量与婴儿发生食物过敏的关系。【方法】采集3~6月人乳喂养婴儿母亲的乳汁,高效液相色谱法法检测其中-αLNA、DHA(n-3组)和LA、AA含量(n-6组);按R.Sporik标准确立婴儿食物过敏,比较食物过敏与正常婴儿母亲乳汁中PUFA含量的差异性。【结果】31例3~6月龄人乳喂养婴儿中10例发生食物过敏,过敏婴儿母亲乳汁中LA、AA及-αLNA含量增高(P<0.05)、DHA含量差异无统计学意义。【结论】食物过敏婴儿的母亲乳汁中-αLNA、LA、AA含量升高,提示人乳PUFA代谢异常可能与婴儿发生食物过敏有关。
【Objective】 To investigate the relationship between polyunsaturated fatty acid (PUFA) content and infant food allergy. 【Method】 Milk from 3 to 6 months old human breastfeeding infants was collected and the content of -αLNA, DHA (n-3) and LA, AA were measured by high performance liquid chromatography (n-6) Standards establish infant food allergies and compare the differences in PUFA content between food allergies and normal infant mothers’ milk. 【Results】 Food allergy occurred in 10 of 31 breastfeeding infants aged 3 to 6 months. The content of LA, AA and -αLNA in milk of allergy infants increased (P <0.05), and there was no significant difference in DHA content. 【Conclusion】 The content of -αLNA, LA and AA in breast milk of food-allergic infants increased, suggesting that abnormal metabolism of PUFA in human milk may be related to food allergy in infants.