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作者将71名18个月～16岁儿童分为疫苗组和安慰剂组,分别在0、1和12个月接种乙型肝炎疫苗和安慰剂.接种后6、24和48小时测体温并观察局部和全身反应;在接种后2周及1、2、3、6、12和18个月时采血,用放射免疫法检测抗-HBs等指标,用P/N或S/N比值估计抗-HBs浓度.疫苗接种后副作用轻微,疫苗组和安慰组之间或每剂间的局部反应均无显著性差异.第1针后2周疫苗组儿童的血清阳转率(≥0.7mIU/ml)为59%,第4周上升到70%,第2针后1个月上升到95%,并维持到第12个月.11岁以下的儿童接种后第8周血清全部阳转.11～17岁年龄组中有2例在12个月
The authors divided 71 children aged 18 months to 16 years into the vaccine group and the placebo group and vaccinated hepatitis B vaccine and placebo at 0, 1, and 12 months, respectively, and observed body temperature at 6, 24, and 48 hours after inoculation Local and systemic reactions. Blood samples were collected at 2 weeks, 1, 2, 3, 6, 12 and 18 months after inoculation. The anti-HBs and other indicators were detected by radioimmunoassay. HBs concentration.After vaccination, the side effects were slight, and there was no significant difference in the local response between the vaccine group and the placebo group or every dose.Serum seroconversion rate (≥0.7mIU / ml) 59%, rising to 70% in the fourth week, 95% in the first month after the second needling, and maintaining to the twelfth month.All the children under the age of 11 were all positive in the eighth week after vaccination, Two of the age groups were at 12 months