Mechanism of the generation of superoxide anion by mitochondria during anoxia and reoxygenation in v

来源 :Acta Pharmacologica Sinica | 被引量 : 0次 | 上传用户:wenqin2000
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AIM: Damages at the level of mitochondria have been reportedafter ischemia and reperfusion of organs. In Order to prove thatthe mitochondria are a soure of free radicals, the mechanism ofgeneration of superoxide anion by mitochondria and its functionaldamage during anoxia and reoxygenation were researched with anin vitro model of isolated mitochondria anoxia-reoxygenation.METHODS: The respiratory activities and functions of isolatedmitochondria were measured by Clark’s electrode with Oxymeter AIM: Damages at the level of mitochondria have been reported after ischemia and reperfusion of organs. In Order to prove that the mitochondria are a soure of free radicals, the mechanism ofgeneration of superoxide anion by mitochondria and its functionaldamage during anoxia and reoxygenation were researched with anin vitro model of isolated mitochondria anoxia-reoxygenation. METHHODS: The respiratory activities and functions of isolated mitochondria were measured by Clark’s electrode with Oxymeter
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