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目的:观察静脉输注大量免疫球蛋白(HDIG)治疗儿童特发性血小板减少性紫癜(TIP)的疗效。方法:联合应用HDIG和皮质激素治疗儿童ITP,观察疗效,并采用统计学方法与对照组作疗效对比。结果:治疗观察组外周血小板上升明显较疗效对照组快,血小板上升达峰值时间也短于对照组(p均<0.05);两组显效率分别为93.8%和63.6%,经统计分析疗效有显著差异(x2=4.18,p<0.05)。结论HDIG联合皮质激素为治疗儿童ITP的有效疗法,具有外周血小板恢复时间快,显效率高,不易复发和较高的安全性等优点,值得临床推广。
Objective: To observe the curative effect of intravenous infusion of massive immunoglobulin (HDIG) on children with idiopathic thrombocytopenic purpura (TIP). Methods: The combined application of HDIG and corticosteroids in children with ITP, observe the effect, and the use of statistical methods and control group for efficacy comparison. Results: The increase of peripheral platelet in treatment group was faster than that in control group, and the peak time of platelet rise was also shorter than that in control group (all p <0.05). The effective rates of the two groups were 93.8% and 63.6% respectively. The statistical analysis showed that the effect was significant Difference (x2 = 4.18, p <0.05). Conclusion HDIG combined with corticosteroids for the treatment of children with ITP effective therapy, with peripheral platelet recovery time, markedly effective, difficult to relapse and higher safety, etc., worthy of clinical promotion.