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本实验观察大鼠实验性心肌梗塞后6小时内腹腔间断注射山莨菪碱(654-2)对急性期和愈合期时梗塞范围(IS)以及左室心肌收缩性(LVMC)恢复的影响。发现在左冠状动脉结扎后6小时,对照组(16例)的坏死区范围占缺血区范围的88.8±2.2％,而给药组(15例)仅占63.7±3.5％(P<0.01)。21天时对照组(12例)的坏死区范围占左室的47.4±1.8％,而给药组(15例)仅占36.2±3.0％(P<0.01)。结扎后21天,给药组的dp/dt_(max)、—dp/dt_(max)和左室收缩期最高压均显著高于对照组相应指标的值。以上结果证明654-2能缩小大鼠实验性心肌梗塞时的IS,并促进梗塞后LVMC的恢复。
This study was designed to observe the effects of intermittent intraperitoneal injection of anisodamine (654-2) within 6 hours after experimental myocardial infarction on the infarct size (IS) and the recovery of left ventricular contractility (LVMC) at acute and healing stages. The necrosis area of the control group (16 cases) accounted for 88.8 ± 2.2% of the ischemic area 6 hours after the left coronary artery ligation, while the administration group (15 cases) accounted for only 63.7 ± 3.5% (P <0.01) . The area of necrosis in the control group (12 cases) at 21 days accounted for 47.4 ± 1.8% of the left ventricle, while the administration group (15 cases) accounted for only 36.2 ± 3.0% (P <0.01). The dp / dt max, dp / dt max and left ventricular systolic pressure of the dosing group were significantly higher than those of the control group on the 21st day after ligation. The above results demonstrate that 654-2 can reduce IS during experimental myocardial infarction in rats and promote LVMC recovery after infarction.