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敌枯双农药属中等毒性,雌性大鼠和小鼠分别经口及腹腔注射的LD_(50)为253和501.5mg/kg。该药对大鼠和小鼠的致畸作用呈剂量效应关系,在高剂量的阳性对照组,即于妊娠第10d给小鼠和大鼠的剂量分别为50和2.5mg/kg,对母鼠的体重出现抑制,有大量的胚胎吸收,其吸收率分别为39.8和46.7％,仔鼠的畸胎发生率分别为56.3和6.8％。1ppm仅见母鼠的体重增长及仔鼠生长发育受抑制,未见仔鼠畸形。0.1ppm组和喷洒三次敌枯双农药的稻谷组的大鼠和小鼠的母鼠和仔鼠均无不良影响。
Dual enemy pesticides are moderately toxic, female rats and mice were orally and intraperitoneally injected LD_ (50) 253 and 501.5mg / kg. The drug teratogenic effect on rats and mice in a dose-response relationship, in the high-dose positive control group, that is, the first 10 days of pregnancy to mice and rats were 50 and 2.5 mg / kg, the female rats Of body weight, with a large number of embryos absorbed, the absorption rates were 39.8 and 46.7%, respectively, and the incidence of teratogenesis in offspring was 56.3 and 6.8%, respectively. 1ppm only to see the growth of mother rats and offspring growth and development was inhibited, no abnormal pups. There was no adverse effect on the maternal and offspring rats and offspring in the 0.1 ppm group and in the paddy group sprayed three times with dwarfing pesticides.