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目的了解监测血液端粒酶(TLM)指标评判结肠癌血液播散和预后的意义。方法结肠癌患者63例和结肠炎患者33例,应用端粒末端重复序列扩增-杂交-酶联免疫技术检测血液TLM。结果结肠癌患者血液TLM阳性率明显高于结肠炎患者(P<0.001)。TLM阳性的结肠癌患者的复发例数明显多于阴性者(P<0.01),其36个月的生存例数明显少于阴性者(P<0.01)。结论动态监测血液TLM指标可以辅助诊断结肠癌血液转移、评判预后。
Objective To understand the significance of monitoring blood telomerase (TLM) in evaluating the blood-dissemination and prognosis of colon cancer. Methods Sixty-three patients with colon cancer and 33 patients with colitis were enrolled in this study. TLM was detected by telomeric repeat amplification-hybridization-enzyme-linked immunosorbent assay. Results The positive rate of TLM in blood of patients with colon cancer was significantly higher than that of patients with colitis (P <0.001). The number of TLM-positive colon cancer patients was significantly higher than that of negative ones (P <0.01). The 36-month survival rate was significantly less than that of negative ones (P <0.01). Conclusion The dynamic monitoring of blood TLM can help diagnose the metastasis of colon cancer and evaluate the prognosis.