论文部分内容阅读
NO_2和亚硝酸离子对电子具有亲合性,因而是活性氧化剂,由于 NO_2分子有不成对的电子:O::H::O,故在 NO_2应有更大的嗜电性和氧化性。氧化剂可包围生物活性化合物的硫氢基,因而能看作是巯基毒或者是《巯基结合物》。作者在本文对 NO_2和亚硝酸离子的巯基结合作用和溶血作用进行了比较分析。研究方法:在第一种实验,研究了 NO_2和亚硝酸钠对谷胱甘肽和二巯基丙醇磺酸钠的—SH 基,以及肺组织水溶性蛋白的—SH 基的氧化速度。NO_2的获得是通过燃烧石英试
NO 2 and nitrite ions have affinity for electrons and are therefore active oxidants. Because NO 2 molecules have unpaired electrons: O :: H :: O, NO 2 should have greater electropositive and oxidative properties. The oxidant may surround the thiol group of the biologically active compound and thus can be considered a thiol poison or a “sulfhydryl conjugate.” In this paper, the sulfhydryl binding and hemolysis of NO 2 and nitrite ions were compared and analyzed. Methods: In the first experiment, the oxidation rate of -SH groups of glutathione and sodium dimercaptopropyl sulfonate by NO 2 and sodium nitrite, and the -SH groups of water-soluble protein in lung tissue were studied. NO 2 is obtained by burning quartz test