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猫,体重2—4公斤,雌雄兼用,按Burn法作成脊猫标本,记录瞬膜反应,血压、心率,寻找利血平处理前后的剂量反应曲线,利血平处理系3毫克/公斤24小时前腹腔注射或48、24小时前给予。 短时利血平处理(前已发现不引起去甲肾上腺素作用敏化)发现可以把拟交感胺分为三类:(1)去甲肾上腺素样胺。在利血平处理动物与正常者,其作用强度是相同的,故可视为主要是直接作用。(2)Tyramine样胺。利血平处理后较少有效;其荆量反应曲线的最
Cats, weighing 2-4 kg, both male and female, according to the Burn method for the formation of ridges cat specimens, recording instantaneous membrane reaction, blood pressure, heart rate, looking for pre and post dose of reserpine treatment dose response curve, reserpine treatment 3 mg / kg 24 hours Before intraperitoneal injection or 48,24 hours before giving. Short-duration reserpine treatment (previously found not to cause norepinephrine sensitization) found that sympathetic amines can be divided into three categories: (1) norepinephrine-like amine. In the treatment of animals and normal reserpine, the role of strength is the same, it can be regarded as the main direct effect. (2) Tyramine-like amine. Reserpine less effective after treatment; the amount of Jing most reaction curve