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目的 探讨病毒性心肌炎 (VMC)和扩张型心肌病 (DCM )患儿粒细胞 -巨噬细胞集落刺激因子 (GM-CSF)与抗 β -肾上腺素受体 (简称 β -受体 )抗体的关系及其意义。 方法 采用放射免疫和免疫印转技术检测了 30例VMC、14例DCM患儿GM -CSF和抗 β -受体抗体。并与对照组 2 5例健康儿对比。 结果 VMC和DCM患儿GM -CSF和抗 β -受体抗体的阳性率分别为 5 4 5 %和 79 5 5 % ,而 2 5例健康儿分别为 8%和 0 (P均<0 0 1) ;且GM -CSF与抗 β -受体抗体的血浆水平呈正相关 (r =0 44 2 3 ,P <0 0 5 )。 结论 GM -CSF和抗 β-受体抗体均参与了VMC和DCM患儿的发病 ,与 β -受体功能异常、心肌自身免疫损伤有关。
Objective To investigate the relationship between granulocyte-macrophage colony stimulating factor (GM-CSF) and anti-β-adrenergic receptor (beta -receptor) in children with viral myocarditis (VMC) and dilated cardiomyopathy And its significance. Methods Radioimmunoassay and immunoblotting were used to detect GM - CSF and anti - β - receptor antibodies in 30 VMCs and 14 DCM children. And compared with 25 healthy children in the control group. Results The positive rates of GM-CSF and anti-β-adrenergic antibodies in children with VMC and DCM were 54.5% and 79.55%, respectively, while those in 25 healthy children were 8% and 0% respectively (all P <0.01) ); And there was a positive correlation between GM-CSF and anti-β-receptor antibody plasma levels (r = 0 44 2 3, P 0 05). Conclusion Both GM-CSF and anti-β-adrenergic antibodies are involved in the pathogenesis of VMC and DCM, which is related to the abnormal function of β-receptor and myocardial autoimmune damage.