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目的探讨病毒性乙型肝炎患者血清sFas、TNF-α、IL-6、IL-8水平与肝细胞凋亡/坏死之间的关系。方法抽取各型乙型肝炎患者静脉血5mL,ELISA法检测sFas、TNF-α、IL-6和IL-8的水平。结果上述4项指标的检出水平基本上依次为:重型乙型肝炎SH-B>慢性乙肝重度CHB-H>慢性乙肝中度CHB-M>急性乙肝AH-B>慢性乙肝轻度CHB-L,各组间差异显著。结论sFas、TNF-α、IL-6和IL-8,4项指标的水平,能够反映肝细胞损害的程度,且与病毒复制、肝细胞凋亡和坏死有内在联系。
Objective To investigate the relationship between serum sFas, TNF-α, IL-6 and IL-8 levels and hepatocyte apoptosis / necrosis in viral hepatitis B patients. Methods Venous blood samples from 5 patients with various types of hepatitis B were collected and the levels of sFas, TNF-α, IL-6 and IL-8 were detected by ELISA. Results The detection rates of the above four indexes were basically as follows: severe hepatitis B SH-B> chronic hepatitis B severe CHB-H> chronic hepatitis B moderate CHB-M> acute hepatitis AH-B> chronic hepatitis B mild CHB-L There was significant difference among groups. Conclusion The levels of sFas, TNF-α, IL-6 and IL-8, 4 indicators can reflect the degree of hepatocellular damage and are intrinsically linked to viral replication, hepatocyte apoptosis and necrosis.