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通过原位聚合法制备了可注射纳米羟基磷灰石/天门冬氨酸-谷氨酸共聚物/硫酸钙复合材料(HA/PAG/CS),采用FTIR、XRD、SEM对复合材料的组成结构、表面形貌及力学性能进行了表征,研究了复合材料在模拟体液(SBF)中的降解性能。结果显示:复合材料无机相羟基磷灰石、硫酸钙与有机相天门冬氨酸-谷氨酸共聚物之间存在化学相互作用,具有良好的抗压强度;7周后,复合材料在SBF中完全降解,降解方式为表面降解;在降解过程中,浸泡液的pH值在6.4～7.4之间变化;复合材料在SBF中浸泡后,其表面能够沉积磷灰石,表明复合材料具有良好的生物活性,有利于植入体与骨组织形成良好的界面结合。
Injectable nano-hydroxyapatite / aspartic acid-glutamic acid copolymer / calcium sulfate composites (HA / PAG / CS) were prepared by in situ polymerization. The composition of the composites was characterized by FTIR, XRD and SEM. , Surface morphology and mechanical properties were characterized, and the degradation of composite materials in simulated body fluid (SBF) was studied. The results show that the composite inorganic hydroxyapatite, calcium sulfate and organic phase aspartic acid - glutamic acid copolymer between the chemical interaction exists, has good compressive strength; 7 weeks after the composite material in the SBF Completely degraded, and degraded way is surface degradation. During the degradation process, pH value of soaking solution varied from 6.4 to 7.4. Apatite could be deposited on the surface of composites after being soaked in SBF, indicating that the composites have good biological Activity, is conducive to implant and bone tissue to form a good interface.