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本文在不同的甲状腺机能状态下,定量研究了大鼠胃溃疡愈合率的变化。大鼠摄取硫氧嘧啶(0.1％水溶液作饮水,饲养10天),引起实验性甲状腺机能低下(甲低组)。给予大鼠0.1％硫氧嘧啶的同时,给予甲状腺素(3μg/100g体重/日)10天,引起实验性甲状腺机能轻度亢进(甲轻亢组)。大鼠用过量甲状腺素(10μg/100g体重/日)10天,引起实验性甲状腺机能亢进(甲亢组)。对照组为正常大鼠,不作任何处理。然后用少量冰醋酸注射入胃粘膜下层造成胃溃疡。各组动物继续给药10天后,测量胃溃疡面积和容积,并计算愈合率。实验结果表明:甲低组溃疡容积(7.71±0.52mm~3;对照组:5.5±0.78mm~3)和面积(8.29±0.90mm~2;对照组:4.39±0.73mm~2)都增大,溃疡容积愈合率(-30±9.4％)和面积愈合率(-50±2.1％)显著降低;甲轻亢组溃疡容积(4.75±0.88mm~3)和面积(4.05±0.93mm~2)都减小,但无统计学意义,溃疡容积愈合率(37±3.8％)和面积愈合率(49±3.2％)显著升高;甲亢组溃疡容积(4.88±0.90mm~3)和面积(5.16±0.74mm~2)与对照组的接近,溃疡容积愈合率(28±1.1％)和面积愈合率(10±1.9％)升高,但无统计学意义。这些发现提示:1.甲状腺素是胃溃疡愈合所必需的激素,甲低时胃溃疡愈合速度减慢;2.小剂量甲状腺素可促进胃溃疡的愈合。
This article quantitatively studied the changes in the healing rate of gastric ulcer in rats under different thyroid function conditions. Rats ingested thiouracil (0.1% aqueous solution for drinking, feeding for 10 days), causing experimental hypothyroidism (hypothyroidism). When rats were given 0.1% thiouracil, thyroxine (3μg/100g body weight/day) was administered for 10 days, causing an experimental hyperthyroidism (a group of hyperthyroidism). Rats were treated with excess thyroxine (10 [mu]g/100 g body weight/day) for 10 days, causing experimental hyperthyroidism (hyperthyroidism group). The control group was normal and no treatment was performed. Then a small amount of acetic acid was injected into the submucosa to cause gastric ulcer. After 10 days of continuous administration of the animals in each group, the gastric ulcer area and volume were measured, and the healing rate was calculated. The experimental results showed that the ulcer volume (7.71±0.52mm~3; control group: 5.5±0.78mm~3) and area (8.29±0.90mm~2; control group: 4.39±0.73mm~2) both increased in the low-dose group. The ulcer healing rate (-30±9.4%) and area healing rate (-50±2.1%) were significantly reduced; the ulcer volume (4.75±0.88mm~3) and area (4.05±0.93mm~2 All decreased, but without statistical significance, ulcer volume healing rate (37±3.8%) and area healing rate (49±3.2%) increased significantly; hyperthyroid group ulcer volume (4.88±0.90mm~3) and area (5.16 (±0.74mm~2) was similar to the control group. The volume healing rate (28±1.1%) and area healing rate (10±1.9%) of the ulcer increased, but there was no statistical significance. These findings suggest that: 1. Thyroxine is a hormone that is necessary for the healing of gastric ulcers, and the healing rate of gastric ulcers is slowed down when hypothyroidism is low; 2. Low-dose thyroxine can promote the healing of gastric ulcers.