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目的:探讨参苓白术颗粒联合嗜热链球菌治疗肠道菌群失调相关性腹泻的临床疗效及对患者胃肠激素的影响。方法:抽取2018年9月至2020年1月在南阳市第二人民医院进行治疗的肠道菌群失调相关性腹泻患者72例，采用信封法随机分为研究组和对照组，每组36例。对照组采用嗜热链球菌治疗，研究组采用参苓白术颗粒联合嗜热链球菌进行治疗。比较两组临床疗效、胃肠激素水平、粪便检查、结肠镜检查评分及不良反应发生情况。分析两种治疗方式对患者血浆胃肠激素的影响。结果:研究组治疗总有效率为97.22%(35/36)，高于对照组的77.78%(28/36)，n P<0.05。治疗后，两组胃动素、胃泌素水平较治疗前降低，生长抑素水平较治疗前升高，且研究组胃动素、胃泌素水平低于对照组，生长抑素水平高于对照组(n P<0.05)。治疗后，两组肠杆菌、乳杆菌、双歧杆菌、双歧杆菌/肠杆菌(B/E)值均较治疗前升高，真菌感染率较治疗前降低，且研究组肠杆菌、乳杆菌、双歧杆菌、B/E值高于对照组，真菌感染率低于对照组(n P<0.05)。治疗后，研究组镜检评分为(0.85±0.14)分，低于对照组的(1.65±0.29)分，n P0.05)。n 结论:参苓白术颗粒联合嗜热链球菌治疗肠道菌群失调相关性腹泻疗效较佳，可改善患者胃肠激素的分泌。“,”Objective:To investigate the effects of Shenling Baizhu granules combined with Streptococcus thermophilus on intestinal dysbacteriosis-induced diarrhea (IDID) and its influences on gastrointestinal hormones.Methods:A total of 72 IDID patients who were treated in Nanyang Second People’s Hospital from September 2018 to January 2020 were enrolled. They were randomly divided into study group and control group by envelope method, with 36 cases in each group. The control group was treated with Streptococcus thermophilus, while study group was treated with Shenling Baizhu granules and Streptococcus thermophilus. The clinical efficacy, gastrointestinal hormone levels, stool examination, colonoscopy scores, and adverse reactions of the two groups were compared. And the effects of the two treatment methods on plasma gastrointestinal hormone were analyzed.Results:The total effective rate of the study group was 97.22% (35/36), higher than 77.78% (28/36) of the control group (n P<0.05). After treatment, the levels of motilin and gastrin in the two groups were lower than those before treatment, and the levels of somatostatin were higher than before treatment (n P<0.05); and the levels of motilin and gastrin in the study group were lower than those in the control group, and the level of SS was higher than that in the control group (n P<0.05). Compared with those before treatment, the Enterobacteriaceae, Lactobacillus, Bifidobacterium and Bifidobacterium/Enterobacferiaceae (B/E) were significantly increased after treatment, while fungal infection rate was decreased after treatment in both groups (n P<0.05); and the Enterobacteriaceae, Lactobacillus, Bifidobacterium and B/E in study group were significantly higher than those in control group, while the fungal infection rate was lower than that in control group after treatment (n P<0.05). After treatment, endoscopy score in study group (0.85±0.14) was significantly lower than that in control group (1.65±0.29),n P0.05.n Conclusions:The curative effect of Shenling Baizhu granules combined with Streptococcus thermophilus is good on IDID, and it can significantly improve the secretion of gastrointestinal hormones.