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山莨菪碱(654—2)为天然植物成份,人工可合成。属抗胆碱类药,具有多种药理作用,使临床适应证不断增多。1 抗呕吐作用 许多抗癌药物都可以引起不同程度的消化道反应。文献报道,用山莨菪碱治疗高剂量顺铂化疗的病人。结果止吐总有效率93％,与对照组相比有显著性差异(p<0.01)。实验显示,山莨菪碱可预防高剂量顺铂所致呕吐。
Anisodamine (654-2) is a natural plant component that is artificially synthesized. Is an anticholinergic drugs, with a variety of pharmacological effects, so that clinical indications continue to increase. Anti-vomiting a lot of anti-cancer drugs can cause varying degrees of gastrointestinal reactions. Reported in the literature, with anisodamine treatment of high-dose cisplatin chemotherapy patients. Results The total effective rate of antiemetic 93%, compared with the control group were significantly different (p <0.01). Experiments show that anisodamine can prevent high doses of cisplatin-induced vomiting.