人们早就认识到β-肾上腺素能受体拮抗剂(以下简称8受体拮抗剂)对抗心律失常的特性。并根据Vaughan Williams对于抗心律失常药的分类把它们归属于第Ⅱ类。本文着重讨论β受体拮抗剂对抗心律失常作用的性质及其分子基础。该类药物构-效关系的研究表明,不同的β受体拮抗剂的抗心律失常作用谱不是固定不变的,有些化合物具有第Ⅰ类或第Ⅱ类药物的作用特性,上述特性可能与临床有关。 People have long recognized the β-adrenergic receptor antagonist (hereinafter referred to as 8 receptor antagonist) anti-arrhythmia characteristics. And classify them into Class II based on Vaughan Williams’s classification of antiarrhythmic drugs. This article focuses on the role of beta-adrenergic antagonists against arrhythmias and their molecular basis. The study of the structure-activity relationship of these drugs shows that the anti-arrhythmic spectrum of different β -receptor antagonists is not fixed, and some compounds have the action characteristics of class I or class II drugs, which may be related to clinical related.