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目的了解广州市黄埔区2012年健康人群中C群脑膜炎奈瑟菌血清杀菌力抗体水平,为防控流脑提供依据。方法选取广州市黄埔区红山街、黄埔街、鱼珠街、长洲街作为本次流脑健康人群监测点,采用随机抽样方法采集健康人群血清,采用血清杀菌力试验检测血清中杀菌力抗体水平。结果共采集250份健康人群血清样本,C群Nm血清杀菌力抗体平均阳性率为54.40%(136/250),保护率为47.20%(118/250);不同年龄组血清杀菌力抗体阳性率及保护率差异均有统计学意义(均P<0.01),其中7~14岁年龄组杀菌力抗体阳性率(30.00%)和保护率(13.33%)最低,15~19岁组的阳性率(83.33%)与保护率(76.67%)最高。结论广州市黄埔区健康人群对C群脑膜炎奈瑟菌存在易感性,应普及适龄儿童A+C群流脑疫苗的免疫接种。
Objective To understand the level of serum bactericidal antibodies against Neisseria meningitides serogroup C in healthy population of Huangpu District in Guangzhou City in 2012 and provide basis for prevention and control of meningitis. Methods We selected Hongshan Street, Huangpu Street, Yuzhu Street and Changzhou Street in Huangpu District of Guangzhou as the monitoring points of this meningitis healthy population. Serum samples of healthy people were collected by random sampling method. Serum bactericidal test Level. Results A total of 250 serum samples from healthy people were collected. The average positive rate of Nm serum bactericidal antibodies in group C was 54.40% (136/250) and the protective rate was 47.20% (118/250). The positive rate of serum bactericidal antibodies in different age groups and (All P <0.01). The positive rate of bactericidal antibody (30.00%) and protection rate (13.33%) in 7-14 years old group was the lowest, while the positive rate of 15-17 years old group was 83.33 %) And protection rate (76.67%) the highest. Conclusion The healthy population in Huangpu District of Guangzhou City is susceptible to Neisseria meningitidis group C, and the immunization of A + C meningitis vaccine should be universal.