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人体内存在自由基与抗自由基系统,其中超氧自由基和含铜锌离子超氧化物歧化酶(Cu-Zn-Superoxide dismutase,SOD-1)是主要一种,两者相对平衡对维持机体内环境稳定起重要作用。为探讨长期血液透析对尿毒症患者血清SOD-1含量的影响,我们观察了不同透析期尿毒症40例患者血清SOD-1含量变化,以探讨其临床意义。 对象和方法 一、对象: (一)尿毒症组:40例(男22,女18),尿毒症患者均为慢性肾功能衰竭晚期,其中慢性肾小球肾炎37例,狼疮性肾炎、高血压病、肾结石各1例。年龄20～67岁,平均46.5岁。透析期由2～42个月不等,平均12.4±7.5个月,均由我院血液透析中心按常规透析。选取其中26例原发病为慢性肾炎患者观察其中一次血液透析前后血清SOD-1含量变化。
There are free radical and anti-free radical system in human body, of which superoxide radical and Cu-Zn-Superoxide dismutase (Cu-Zn-Superoxide dismutase, SOD-1) is the main one, the relative balance between the two to maintain the body Environmental stability plays an important role. To investigate the effect of chronic hemodialysis on serum SOD-1 in patients with uremia, we observed the changes of serum SOD-1 levels in 40 patients with uremia at different dialysis stages to investigate its clinical significance. Subjects and methods First, the object: (a) uremia group: 40 cases (male 22, female 18), uremia are chronic renal failure in advanced stage, of which 37 cases of chronic glomerulonephritis, lupus nephritis, hypertension Diseases, kidney stones in 1 case. Age 20 to 67 years old, average 46.5 years old. Dialysis period ranged from 2 to 42 months, an average of 12.4 ± 7.5 months, by our hospital hemodialysis center according to conventional dialysis. Twenty-six patients with chronic nephritis were selected to observe the change of serum SOD-1 level before and after hemodialysis.