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目的探讨慢性乙型肝炎病毒(HBV)感染者血浆甘露糖结合凝集素(MBL)含量对慢性HBV感染患者疾病进展的影响。方法采用酶联免疫吸附法(ELISA)对395例慢性HBV感染者[包括244例慢性乙型肝炎(CHB)、73例代偿性肝硬化(LC)、78例失代偿性LC]和88例正常对照组血浆MBL的含量进行检测。结果血浆MBL浓度在轻度、中度、重度CHB及代偿性和失代偿性LC患者分别为(5.701±2.419)、(5.462±2.378)、(4.609±2.116)、(4.876±2.175)和(4.528±2.045)mg/L,明显高于正常对照组(2.187±1.392)mg/L,差异均有统计学意义(P均<0.01);轻度与中度CHB患者血浆MBL浓度相近(P>0.05),高于重度CHB、代偿性和失代偿性LC患者(P均<0.05);中度CHB与代偿性LC患者血浆MBL浓度相近(P>0.05),高于重度CHB、失代偿性LC患者(P均<0.05);重度CHB与代偿性LC和失代偿性LC患者血浆MBL浓度相近(P均>0.05)。结论慢性HBV感染者血浆MBL含量明显高于正常对照组;血浆MBL含量对CHB患者疾病进展有一定的影响。
Objective To investigate the effect of plasma mannose binding lectin (MBL) levels in patients with chronic hepatitis B virus infection on the progression of diseases in patients with chronic HBV infection. Methods 395 patients with chronic HBV infection (including 244 CHB, 73 LC, 78 decompensated LC) and 88 Cases of normal control plasma MBL levels were detected. Results The plasma concentrations of MBL were (5.701 ± 2.419), (5.462 ± 2.378), (4.609 ± 2.116), (4.876 ± 2.175) and (4.876 ± 2.175) in patients with mild, moderate, severe CHB and compensated and decompensated LC respectively (4.528 ± 2.045) mg / L, which was significantly higher than that of the normal control group (2.187 ± 1.392) mg / L, all of which were statistically significant (all P <0.01) > 0.05), higher than that in severe CHB, compensatory and decompensated LC patients (all P <0.05). The plasma concentrations of MBL in moderate CHB and compensated LC patients were similar (P> 0.05) Patients with decompensated LC had similar plasma MBL concentrations (all P <0.05). Serum MBL concentrations in patients with severe CHB and compensated LC and decompensated LC were similar (all P> 0.05). Conclusion Plasma MBL levels in patients with chronic HBV infection were significantly higher than those in normal controls. Plasma MBL levels had some effect on disease progression in patients with CHB.