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健康志愿者１０例和老年消化性溃疡患者６例单剂量口服４０ｍｇ法莫替丁（Ｆａｍ）后，体内处置符合一室开放模型，老年患者Ｔ１／２为０．５９±１．８１ｈ，药－时曲线下面积８６６．５±１９４ｎｇ·ｍｌ－１·ｈ－１，肾清除率和总清除率分别为３２９±４５．５ｍｌ／ｍｉｎ和４３８±３４ｍｌ／ｍｉｎ，２４ｈＦａｍ原型经肾排出量为总剂量的２１．５％，与健康志愿者相比，消除明显减慢，血药浓度水平升高，临床使用时需调整剂量，避免由于药物在体内蓄积而引起的不良反应。
10 healthy volunteers and 6 elderly patients with peptic ulcer oral administration of 40mg famotidine (Fam), in vivo treatment consistent with an open chamber model, T1 / 2 in elderly patients was 0.59 ± 1.81h, drug- The area under the curve was 866.5 ± 194ng · ml-1 · h-1, the renal clearance rate and total clearance rate were 329 ± 45.5ml / min and 438 ± 34ml / min respectively. The 24hFam prototype renal excretion was the total dose 21.5%. Compared with healthy volunteers, the elimination obviously slowed down and the plasma concentration increased. In clinical use, the dosage should be adjusted to avoid adverse reactions caused by accumulation of drugs in the body.