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长期以来,人们渴望发展一种高效、简便、能反复使用的非手术性药物流产方法。近十余年来,前列腺素(Prostaglandin,简称 PG)抗早孕临床研究的发展,为人们实现理想的药物流产开辟了道路。本文就 PG抗早孕概况、作用机理、临床应用及进一步发展的某些具体问题作一综合性论述。一、国外 PG 药物抗早孕进展概况用于抗早孕的 PG 主要是 PGE 和 PGF 族及其类似物。根据 WHO 的资料,十余年来其进展可分为三个阶段(附表)。(一)第一阶段(1970～1973):经典前列腺素(Classical Prostaglandin)抗早孕:Karim(1971)首先对月经延迟2
For a long time, people are eager to develop an efficient, simple and reusable non-surgical medical abortion method. In the recent ten years, the development of prostaglandin (PG) anti-early pregnancy clinical research has opened the way for people to realize the ideal medical abortion. In this paper, PG anti-early pregnancy overview, mechanism of action, clinical application and further development of some specific issues for a comprehensive discussion. First, the progress of anti-pregnancy in foreign PG drug Overview PG for anti-early pregnancy is mainly PGE and PGF family and its analogues. According to the WHO, its progress can be divided into three phases (schedule) for more than a decade. (A) the first phase (1970 ~ 1973): Classical prostaglandin anti-early pregnancy: Karim (1971) first of the delay of 2