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T 细胞对IgA 的分泌与合成有调节作用,它可以作为抗体类别转换细胞使膜IgM(mIgM)细胞分化为膜IgA(mIgA)细胞,并且能够使膜IgA 细胞增殖和转化为分泌IgA 抗体的浆细胞。这种调节作用被认为是通过一种或多种淋巴因子所介导的,在这些淋巴因子中,已知白细胞介素5(IL-5)能够增强IgA 的分泌,但是,尚不知它是作用于B 细胞分化的哪一个阶段.IL-4和D10G4.1细胞上清(含IL-4和IL-5)能够增加派伊尔氏淋巴结节(Peyer′spatches)内非T 淋巴细胞IgA 的分泌量,分别达十倍和四倍。如用重组的白细胞介素5(rIL-5)代替这些细胞的上清液,也
T cells, which regulate the secretion and synthesis of IgA, can differentiate membrane IgM (mIgM) cells into membrane IgA (mIgA) cells as antibody classes and proliferate and transform membrane IgA cells into serum secreting IgA antibodies cell. This modulation is thought to be mediated by one or more lymphokines, of which interleukin 5 (IL-5) is known to enhance IgA secretion but it is not yet known whether it is an effect At which stage of B cell differentiation IL-4 and D10G4.1 cell supernatants (including IL-4 and IL-5) are able to increase the secretion of IgA from non-T lymphocytes in Peyer’s patches Amount, respectively, up to ten times and four times. Such as replacing the supernatant of these cells with recombinant interleukin 5 (rIL-5), also