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目的对狼疮脑病临床病变特点及预后进行总结,并对这一疾病所致认知功能损伤的发生及逆转情况进行分析。方法对98例狼疮脑病进行回顾性分析。结果按症状分4组:认知功能损伤组、癫痫组、脑血管病组及头痛组,4组的就诊年龄、首发症状到神经系统损害症状出现的时间与预后无关联(P>0.05)。认知功能损伤组、癫痫组及头痛组的预后较脑血管病组的预后好(χ2=46.73,P=0.001)。狼疮脑病所致认知功能损伤发生率为41%,经积极治疗后的逆转率为90%。结论狼疮脑病中不同症状的患者预后有明显差异,本疾病所致认知功能损伤发生率及积极治疗后逆转率较高,应引起临床足够重视。
Objective To summarize the clinical features and prognosis of lupus encephalopathy and to analyze the occurrence and reversal of cognitive impairment caused by this disease. Methods 98 cases of lupus encephalopathy were retrospectively analyzed. The results were divided into 4 groups according to symptoms: there was no correlation between the age of onset of symptoms, the onset time of neurological damage and the prognosis of cognitive impairment group, epilepsy group, cerebrovascular disease group and headache group (P> 0.05). The prognosis of cognitive impairment group, epilepsy group and headache group was better than that of cerebrovascular disease group (χ2 = 46.73, P = 0.001). The prevalence of cognitive impairment due to lupus and encephalopathy was 41%, and the rate of reversal after active treatment was 90%. Conclusions The prognosis of patients with different symptoms in lupus encephalopathy is obviously different. The incidence of cognitive impairment caused by this disease and the high reversal rate after active treatment should be paid enough attention in clinic.