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目的比较异丙酚颈内动脉输注与静脉内输注对中低温体外循环大鼠脑内氨基酸含量和外周循环的影响。方法建立大鼠CPB模型,随机分成5组,假手术对照组(SC),体外循环组(CPB)组,CPB+propofol2mg/(kg·h)静脉给药组(P2V组),CPB+propofol2mg/(kg·h)颈内动脉给药组(P2A组)。结果病理检查显示,P10V组和P2A组病理损伤轻于CPB组;对脑内Glu,Asp和Gly具有抑制作用,对GABA具有促进作用。上述指标P2V组与CPB组没有差异。P10V组出现HR增快,MAP下降,而2mg/(kg·h)的异丙酚无明显的循环抑制。结论异丙酚颈内动脉连续输注具有脑保护作用,且剂量小,对循环的抑制轻微。为异丙酚脑保护研究提供新的探索。
Objective To compare the effect of propofol intracarotid artery infusion and intravenous infusion on brain amino acid levels and peripheral circulation in hypothermic cardiopulmonary bypass rats. Methods Rat model of CPB was established and randomly divided into 5 groups: sham operation control group (SC), CPB group, CPB propofol 2 mg / (kg · h) intravenous group (P2V group), CPB propofol 2 mg / (kg · h) carotid artery administration group (P2A group). Results Pathological examination showed that pathological damage in P10V and P2A groups was less than that in CPB group. Glu, Asp and Gly were inhibited in brain and GABA was promoted. There was no difference between the above parameters in P2V group and CPB group. P10V group HR increased, MAP decreased, while 2mg / (kg · h) of propofol no significant inhibition of circulation. Conclusion Continuous infusion of propofol into the internal carotid artery has neuroprotective effects with a small dosage and slight inhibition of circulation. Propofol for brain protection research to provide a new exploration.