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目的：观察东菱精纯克栓酶对胃癌及鼻咽癌荷瘤裸鼠转移及血液流变学的影响。方法：用人胃癌及鼻咽癌细胞株分别接种裸鼠背部皮下，同时每周２次裸鼠腹腔内注射东菱精纯克栓酶，７０天处死裸鼠，观察裸鼠转移情况及血液流变学变化。结果：东菱精纯克栓酶治疗组胃癌及鼻咽癌荷瘤裸鼠的转移率均明显低于对照组（Ｐ＜００１）；胃癌及鼻咽癌荷瘤裸鼠全血粘度、血浆粘度及红细胞压积低于对照组，差异有显著性意义（Ｐ＜００５）。结论：东菱精纯克栓酶对胃癌及鼻咽癌荷瘤裸鼠转移能力有明显的抑制作用，并能降低血液的粘度。
Objective: To observe the effect of Dongling Jingchun glucetabolus on metastasis and hemorheology in nude mice bearing gastric cancer and nasopharyngeal carcinoma. METHODS: Human gastric cancer and nasopharyngeal carcinoma cell lines were inoculated subcutaneously on the back of nude mice, and nude mice were intraperitoneally injected with Dongling Jingchun glucetabolus twice a week. Nude mice were killed at 70 days. The metastasis and blood rheology of nude mice were observed. Learn to change. RESULTS: The metastasis rate of nude mice with gastric carcinoma and nasopharyngeal carcinoma in the treatment group of Dongling Jingchun glucetabolus was significantly lower than that of the control group (P<001); the blood viscosity of nude mice bearing gastric carcinoma and nasopharyngeal carcinoma was measured. Plasma viscosity and hematocrit were lower than those in the control group, with significant differences (P<0. 05). Conclusion: Dongling Jingchun glucetabolus can obviously inhibit the metastasis capacity of nude mice bearing gastric cancer and nasopharyngeal carcinoma and reduce the viscosity of blood.