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用吡嗪酰胺(PZA)与其它抗结核的杀菌药物联合治疗结核病可杀灭病人体内的结核持久菌,并明显缩短疗期。尽管 Shepard 等报告单用 PZA对鼠足垫内麻风菌的繁殖无抑制作用,但小鼠的试验结果并不总能直接推断用于人类。由于 PZA 在巨噬细胞酸性环境中活性强,而麻风菌主要在巨噬细胞中,因此作者将此药作为联合化疗药物之一治疗麻风并观察其疗效。方法:病例为印度中部 JALMA 研究所门诊未治 BL 和 LL 病人,男111例,女8例,年龄15～50岁。所有病例在开始2个月均住院治疗。疗前常规体检,作皮肤涂片并记录 BI 和 MI,作皮肤活检,血、尿和肝、肾功能检查。疗程中定期重复上述检查。在治疗2年末和4～5年时作阴囊皮肤活检并接种至正常小鼠的足垫以检测持久菌。治疗方案系在利福平、氯苯吩嗪、异烟肼和氨硫脲中选择2～3
Treatment of tuberculosis with pyrazinamide (PZA) and other antituberculous bactericidal drugs can kill the persistent tuberculosis of tuberculosis in patients and significantly shorten the treatment period. Although Shepard et al. Report that PZA alone does not inhibit the propagation of Leprosy in mouse footpad, the test results in mice are not always directly inferred for use in humans. Since PZA is highly active in the macrophage acidic environment and Leprosy is predominantly in macrophages, the authors treated the drug as one of the combined chemotherapeutic agents for leprosy and observed its efficacy. Methods: The cases were outpatient BL and LL patients from JALMA Institute in Central India. There were 111 males and 8 females, aged 15 to 50 years old. All cases were hospitalized in the first 2 months. Pre-treatment physical examination for skin smear and record BI and MI for skin biopsy, blood, urine and liver and kidney function tests. Periodically repeat the above examination during treatment. Scrotal skin biopsies were performed at the end of 2 and 4 to 5 years of treatment and inoculated into foot pads of normal mice for the detection of persistent bacteria. Treatment programs in the rifampin, chlorphenazine, isoniazid and thiourea in the choice of 2 to 3