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目的:对宫颈薄层液基细胞学检查结果为不典型鳞状上皮细胞(ASC-US)的患者,通过高危型人乳头瘤病毒(HPV)DNA检测进行临床分流管理。方法:对662例ASC-US患者进行高危型HPV-DNA检测及宫颈活检病理学检查。结果:高危型HPV-DNA检测结果阳性为215例,阳性率为32.48%。病理结果为慢性宫颈炎、宫颈上皮内瘤样病变(CIN)Ⅰ、CINⅡ、CINⅢ和宫颈浸润癌的患者高危型HPV病毒阳性所占比例为17.10%、57.33%、78.85%、93.10%、100%。结论:高危型HPV阳性预示着可能有宫颈高度癌前期病变的存在,或有可能发展为宫颈高度癌前期病变,HPV阴性则意味着几乎不会发生宫颈癌,及时合理地检测高危型HPV对宫颈病变的临床处理起着科学分流管理的作用。
OBJECTIVE: To perform clinical shunt management of high-risk human papillomavirus (HPV) DNA in patients with cervical lamina fluid-based cytological findings of atypical squamous epithelial cells (ASC-US). Methods: 662 ASC-US patients were examined by high-risk HPV-DNA and cervical biopsy. Results: High-risk HPV-DNA test results were positive in 215 cases, the positive rate was 32.48%. The positive rate of high-risk HPV was 17.10%, 57.33%, 78.85%, 93.10% and 100% in patients with chronic cervicitis, cervical intraepithelial neoplasia (CIN) Ⅰ, CINⅡ, CINⅢ and cervical invasive carcinoma . Conclusion: High-risk HPV positive predicts cervical precancerous lesions may exist, or may develop into a high degree of cervical precancerous lesions, HPV-negative means that almost no cervical cancer occurs, timely and reasonable detection of high-risk HPV on the cervix The clinical treatment of lesions plays a role of scientific diversion management.