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目的：研究急性重症胆管炎患者发生全身炎症反应综合征（ＳＩＲＳ） 和多器官功能不全综合征（ＭＯＤＳ） 的情况及两者之间的关系，从而为防治ＭＯＤＳ、降低急性重症胆管炎患者死亡率提供治疗对策。方法：选择１９８９ 年１ 月～１９９８ 年１２ 月间收治的１０４ 例急性重症胆管炎患者的临床资料，按照１９９１ 年８ 月ＡＣＣＰ和ＳＣＣＭ 会议的诊断标准，比较ＳＩＲＳ和ＭＯＤＳ的发病率。结果：所有急性重症胆管炎患者都发生ＳＩＲＳ，发病率为１００ ％ ，发生ＭＯＤＳ４１例，发病率为３９－４ ％ ，死亡２１ 例，均发生ＭＯＤＳ，死亡率为２０－２ ％ 。结论：所有急性重症胆管炎患者均发生ＳＩＲＳ，ＳＩＲＳ至ＭＯＤＳ是一个连续的发展过程，ＭＯＤＳ有很高的死亡率，早期诊断ＳＩＲＳ，并积极调控机体炎症反应，可能是改善急性重症胆管炎患者预后的关键
Objective: To study the incidence of systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS) in patients with acute cholangitis and the relationship between them, so as to prevent and cure MODS and reduce mortality in patients with acute severe cholangitis Provide treatment measures. Methods: The clinical data of 104 patients with acute cholangitis admitted from January 1989 to December 1998 were selected. The incidence of SIRS and MODS was compared with the diagnostic criteria of ACCP and SCCM in August 1991. Results: SIRS occurred in all acute cholangitis patients. The incidence rate was 100%. There were 41 MODS cases with the incidence of 39-4% and 21 deaths. MODS occurred and the mortality rate was 20-2%. CONCLUSIONS: SIRS occurs in all patients with acute cholangitis. SIRS to MODS is a continuous development. MODS has a high mortality rate, early diagnosis of SIRS, and active regulation of inflammatory reaction in the body, which may be to improve the prognosis of patients with acute cholangitis key