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目的了解青少年艾滋病抗病毒治疗的基本特点,为艾滋病防控和综合治疗提供科学依据。方法采集2002年1月-2015年1月(AIDS)在北京佑安医院接受抗病毒治疗的青少年艾滋病病毒(HIV)感染者/艾滋病(AIDS)病人的临床资料,分析和探讨青少年抗病毒治疗的特点。结果收录的37例HIV感染者/AIDS病人中,性传播占91.89%。基线时HIV-1病毒载量为(4.40±4.83)Log拷贝/mL,抗病毒治疗5年后,病毒载量降至(0.87±0.82)Log拷贝/mL,差异有统计学意义(t=3.149,P=0.003)。病毒载量完全抑制者所占的比例由0增加至94.7%(P<0.001);抗病毒治疗5年时CD4+T淋巴细胞计数由基线的(179±102)个/μL升高至(732±136)个/μL,治疗前后比较差异有统计学意义(t=17.118,P<0.001)。结论抗病毒治疗可有效抑制青少年HIV感染者/AIDS病人的病毒载量,改善其免疫功能,应推广HIV感染青少年的抗病毒治疗,加强艾滋病宣传教育,以控制HIV在青少年人群的传播。
Objective To understand the basic characteristics of HIV / AIDS treatment for adolescents and provide a scientific basis for AIDS prevention and control and comprehensive treatment. Methods The clinical data of HIV / AIDS patients receiving antiretroviral therapy from January 2002 to January 2015 (AIDS) in Beijing You’an Hospital were collected and analyzed. The clinical data of adolescent antiviral therapy Features. Results Among 37 cases of HIV / AIDS patients, 91.89% were sexually transmitted. At baseline, the HIV-1 viral load was (4.40 ± 4.83) log copies / mL. After 5 years of anti-viral therapy, the viral load decreased to (0.87 ± 0.82) log copies / mL, with a statistically significant difference (t = 3.149 , P = 0.003). The percentage of patients with complete inhibition of viral load increased from 0 to 94.7% (P <0.001). The CD4 + T lymphocyte count increased from baseline (179 ± 102) / μL to (732) at 5 years ± 136) pcs / μL. The difference between before and after treatment was statistically significant (t = 17.118, P <0.001). Conclusions Antiviral therapy can effectively reduce the viral load and improve the immune function of HIV / AIDS-infected adolescents. It should be used to promote the anti-viral treatment of HIV-infected adolescents and AIDS awareness and education so as to control the spread of HIV in adolescent populations.