CREST综合征是一轻型、缓进和进行性系统性硬皮病,国内文献报告甚少(李嘉猷,等.中华内科杂志 1983;22,377)。我院曾遇1例,现报道如下: 患者,女,42岁,教师。从1984年起双手皮肤受冷后开始出现发白、青紫,1986年起双手指及颈部皮肤紧张、变硬,曾多次入院治疗。查体:T 37℃,BP 16/10 kPa,表情较呆板,面颊部可见散在的扩张的毛细血管,张口稍受限。双肺呼吸音粗糙,心界不大,心率75min~(-1),胸骨左缘Ⅱ～Ⅲ肋间可闻及Ⅱ/6级全收缩期吹风样杂音,不传导。肝脾未及。双手 CREST syndrome is a light, slow and progressive systemic scleroderma, the domestic literature reported little (Li Jia 猷, et al. Journal of Internal Medicine 1983; 22,377). A case of our hospital has been reported as follows: Patients, female, 42 years old, teacher. Since 1984, his hands began to appear cold and white skin, bruising, his fingers and neck skin since 1986, nervous, hardened, has repeatedly hospitalized. Physical examination: T 37 ℃, BP 16/10 kPa, the expression is more rigid, visible expansion of the cheeks scattered capillaries, mouth slightly limited. Breathing sounds rough lungs, heart is not big, heart rate 75min ~ (-1), left sternal border Ⅱ ~ Ⅲ intercostal can smell and Ⅱ / 6 systolic hair-like murmurs, no conduction. Liver and spleen not yet. Hands